Microbial Fermentation Technology Market Size, Share & Trends Analysis Report By Application (Antibiotics, Vaccines), By End-user (Biopharmaceutical Companies), By Region, And Segment- Global Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2023-2032

The global microbial fermentation technology market size was exhibited at USD 31.98 billion in 2022 and is projected to hit around USD 56.73 billion by 2032, growing at a CAGR of 5.9% during the forecast period 2023 to 2032.

Key Pointers:

• The antibiotics segment captured the largest market share of 32.19% in 2022
• The CMOs and CDMOs segment dominated the market and accounted for the highest share of 42.18% in 2022.
• Owing to the faster and more stable growth pattern of microorganisms, the use of fermentation in small molecule synthesis is expected to witness lucrative growth throughout the forecast period
• Furthermore, the demand for biologics and biopharmaceuticals is increasing in Japan. As a result, Japanese firms are undertaking various strategic initiatives to enhance their domestic biomanufacturing operations
• North America is anticipated to witness the fastest growth throughout the forecast period owing to the presence of a well-established biopharmaceutical industry coupled with a high number of fermentation solution providers
• Continuous efforts by key players to improve their product offerings are also contributing to North America’s regional market growth
• Asia Pacific dominated the market and accounted for the highest revenue share of 45.11% in 2022. 

Microbial Fermentation Technology Market Report Scope

The factors such as increasing demand for biologics, development of innovative therapies based on smaller biologic drug substances, and advancements in microbial fermentation platforms/ technologies have driven the growth of the industry in recent years. In the past few years, the microbial fermentation space is witnessing an upsurge in demand owing to the exponential growth in the microbial biopharmaceutical industry. The advantages offered by microbial expression systems such as short-development timelines, higher expression levels, and less media cost as compared to mammalian cell culture have majorly contributed to the resurgence in interest in using microbial organisms in manufacturing processes. Overall, microbial fermentation technology offers higher yields, faster development, better scalability, reduced variation between batches along with lower production costs.

Amidst the COVID-19 pandemic, the microbial fermentation technology market was relatively less impacted. The surge in demand for various biologics resulted in growing attention toward microbial biotechnology. Market players involved in COVID-19 vaccine development and manufacturing have also relied on microbial expression systems for vaccine development. For instance, the Pfizer-BioNTech vaccine is based on bacterial fermentation for the production of DNA plasmids required for vaccine manufacturing.

Furthermore, increasing demand for microbial contract manufacturing services is anticipated to supplement the market growth. Currently, more than 115 industry participants are actively engaged in offering microbial fermentation services. Thus, the market is highly fragmented with the presence of well-established players such as AbbVie Contract Manufacturing, Lonza, and others. Such a high number of service providers in this market space are likely to spur market growth in the coming years.

Furthermore, yeasts are a commonly used eukaryotic host for the production of heterologous proteins and provide several advantages in the manufacturing of therapeutic recombinants. The use of yeast as a cell factory has various advantages, including simplicity of genetic manipulation, high cell density development, and post-translational modification possibilities. Thus, the rising focus of various research institutes and scientists on exploring the potential of yeast cells in therapeutic or clinical applications will expedite market growth in the near future.

Microbial Fermentation Technology Market Segmentation